論文 - 詳細
| RRC ID | 45772 |
|---|---|
| 著者 | Kirienko NV, Ausubel FM, Ruvkun G. |
| タイトル | Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
In the arms race of bacterial pathogenesis, bacteria produce an array of toxins and virulence factors that disrupt core host processes. Hosts mitigate the ensuing damage by responding with immune countermeasures. The iron-binding siderophore pyoverdin is a key virulence mediator of the human pathogen Pseudomonas aeruginosa, but its pathogenic mechanism has not been established. Here we demonstrate that pyoverdin enters Caenorhabditis elegans and that it is sufficient to mediate host killing. Moreover, we show that iron chelation disrupts mitochondrial homeostasis and triggers mitophagy both in C. elegans and mammalian cells. Finally, we show that mitophagy provides protection both against the extracellular pathogen P. aeruginosa and to treatment with a xenobiotic chelator, phenanthroline, in C. elegans. Although autophagic machinery has been shown to target intracellular bacteria for degradation (a process known as xenophagy), our report establishes a role for authentic mitochondrial autophagy in the innate immune defense against P. aeruginosa. |
| 巻・号 | 112(6) |
| ページ | 1821-6 |
| 公開日 | 2015-2-10 |
| DOI | 10.1073/pnas.1424954112 |
| PII | 1424954112 |
| PMID | 25624506 |
| PMC | PMC4330731 |
| MeSH | Animals Caenorhabditis elegans Fluorescence HEK293 Cells Homeostasis / drug effects* Humans Immunity, Innate / immunology* Iron / metabolism Microscopy, Confocal Mitophagy / drug effects* Mitophagy / immunology Oligopeptides / metabolism Oligopeptides / toxicity* Phenanthrolines Pseudomonas aeruginosa / metabolism* Siderophores / metabolism Siderophores / toxicity* |
| IF | 9.412 |
| 引用数 | 82 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1779 tm4248 |