論文 - 詳細
| RRC ID | 45785 |
|---|---|
| 著者 | Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. |
| タイトル | Kynurenic acid is a nutritional cue that enables behavioral plasticity. |
| ジャーナル | Cell |
| Abstract |
The kynurenine pathway of tryptophan metabolism is involved in the pathogenesis of several brain diseases, but its physiological functions remain unclear. We report that kynurenic acid, a metabolite in this pathway, functions as a regulator of food-dependent behavioral plasticity in C. elegans. The experience of fasting in C. elegans alters a variety of behaviors, including feeding rate, when food is encountered post-fast. Levels of neurally produced kynurenic acid are depleted by fasting, leading to activation of NMDA-receptor-expressing interneurons and initiation of a neuropeptide-y-like signaling axis that promotes elevated feeding through enhanced serotonin release when animals re-encounter food. Upon refeeding, kynurenic acid levels are eventually replenished, ending the elevated feeding period. Because tryptophan is an essential amino acid, these findings suggest that a physiological role of kynurenic acid is in directly linking metabolism to activity of NMDA and serotonergic circuits, which regulate a broad range of behaviors and physiologies. |
| 巻・号 | 160(1-2) |
| ページ | 119-31 |
| 公開日 | 2015-1-15 |
| DOI | 10.1016/j.cell.2014.12.028 |
| PII | S0092-8674(14)01634-1 |
| PMID | 25594177 |
| PMC | PMC4334586 |
| MeSH | Animals Behavior, Animal* Caenorhabditis elegans / metabolism* Cues Fasting Feeding Behavior* Interneurons / metabolism Kynurenic Acid / metabolism* Kynurenine / metabolism Neurons / metabolism Neuropeptides / metabolism Receptors, N-Methyl-D-Aspartate / metabolism Serotonin Signal Transduction Transaminases / metabolism Tryptophan / metabolism |
| IF | 38.637 |
| 引用数 | 35 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4529 tm3785 |