論文 - 詳細
| RRC ID | 45809 |
|---|---|
| 著者 | Morales-Martínez A, Dobrzynska A, Askjaer P. |
| タイトル | Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans. |
| ジャーナル | J Cell Sci |
| Abstract |
The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and separate functions in regulation of nuclear organization, gene expression and cell differentiation. We report here that emerin (EMR-1) and LEM domain protein 2 (LEM-2) are expressed in all tissues throughout Caenorhaditis elegans development but their relative distribution differs between cell types. The ratio of EMR-1 to LEM-2 is particularly high in contractile tissues, intermediate in neurons and hypodermis and lowest in intestine and germ line. We find that LEM-2 is recruited earlier than EMR-1 to reforming nuclear envelopes, suggesting the presence of separate mitotic membrane compartments and specific functions of each protein. Concordantly, we observe that nuclei of lem-2 mutant embryos, but not of emr-1 mutants, have reduced nuclear circularity. Finally, we uncover a so-far-unknown role of LEM-2 in nuclear separation and anchoring of microtubule organizing centers. |
| 巻・号 | 128(6) |
| ページ | 1090-6 |
| 公開日 | 2015-3-15 |
| DOI | 10.1242/jcs.164202 |
| PII | jcs.164202 |
| PMID | 25653391 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins Cell Nucleus / physiology* Cell Nucleus / ultrastructure* Fluorescent Antibody Technique Image Processing, Computer-Assisted Membrane Proteins / genetics Membrane Proteins / metabolism* Nuclear Envelope / physiology* Nuclear Proteins / genetics Nuclear Proteins / metabolism* |
| IF | 4.573 |
| 引用数 | 12 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1582 |