論文 - 詳細
| RRC ID | 45899 |
|---|---|
| 著者 | Zahratka JA, Williams PD, Summers PJ, Komuniecki RW, Bamber BA. |
| タイトル | Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor. |
| ジャーナル | J Neurophysiol |
| Abstract |
Monoamines and neuropeptides modulate neuronal excitability and synaptic strengths, shaping circuit activity to optimize behavioral output. In C. elegans, a pair of bipolar polymodal nociceptors, the ASHs, sense 1-octanol to initiate escape responses. In the present study, 1-octanol stimulated large increases in ASH Ca(2+), mediated by L-type voltage-gated Ca(2+) channels (VGCCs) in the cell soma and L-plus P/Q-type VGCCs in the axon, which were further amplified by Ca(2+) released from intracellular stores. Importantly, 1-octanol-dependent aversive responses were not inhibited by reducing ASH L-VGCC activity genetically or pharmacologically. Serotonin, an enhancer of 1-octanol avoidance, potentiated 1-octanol-dependent ASH depolarization measured electrophysiologically, but surprisingly, decreased the ASH somal Ca(2+) transients. These results suggest that ASH somal Ca(2+) transient amplitudes may not always be predictive of neuronal depolarization and synaptic output. Therefore, although increases in steady-state Ca(2+) can reliably indicate when neurons become active, quantitative relationships between Ca(2+) transient amplitudes and neuronal activity may not be as straightforward as previously anticipated. |
| 巻・号 | 113(4) |
| ページ | 1041-50 |
| 公開日 | 2015-2-15 |
| DOI | 10.1152/jn.00665.2014 |
| PII | jn.00665.2014 |
| PMID | 25411461 |
| PMC | PMC4329441 |
| MeSH | 1-Octanol / pharmacology Action Potentials* Animals Axons / metabolism Axons / physiology Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Calcium Channels / metabolism Calcium Signaling* Nociceptors / drug effects Nociceptors / metabolism* Nociceptors / physiology Serotonin / pharmacology* |
| IF | 2.234 |
| 引用数 | 18 |
| WOS 分野 | PHYSIOLOGY NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2654 |