Reference - Detail
| RRC ID | 45905 |
|---|---|
| Author | Zhu Z, Liu J, Yi P, Tian D, Chai Y, Li W, Ou G. |
| Title | A proneural gene controls C. elegans neuroblast asymmetric division and migration. |
| Journal | FEBS Lett |
| Abstract |
Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified Caenorhabditiselegans mutants of a proneural transcription factor (TF) lin-32, in which Q neuroblasts are produced. We showed that LIN-32 functions in parallel with a storkhead TF, HAM-1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin-32 alleles. Consistently, lin-32 is expressed throughout Q neuroblast lineage, suggesting that LIN-32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development. |
| Volume | 588(7) |
| Pages | 1136-43 |
| Published | 2014-4-2 |
| DOI | 10.1016/j.febslet.2014.02.036 |
| PII | S0014-5793(14)00156-2 |
| PMID | 24589937 |
| MeSH | Alleles Animals Asymmetric Cell Division* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cell Movement* Cell Size Gene Expression Regulation, Developmental Microscopy, Fluorescence Neurons / physiology* Time-Lapse Imaging Transcription Factors / genetics* Transcription Factors / metabolism |
| IF | 3.057 |
| Times Cited | 7 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm1446 tm1768 |