| RRC ID |
45961
|
| 著者 |
Donnelly JL, Clark CM, Leifer AM, Pirri JK, Haburcak M, Francis MM, Samuel AD, Alkema MJ.
|
| タイトル |
Monoaminergic orchestration of motor programs in a complex C. elegans behavior.
|
| ジャーナル |
PLoS Biol
|
| Abstract |
Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and turns to change its direction of locomotion. We show that the tyramine receptor SER-2 acts through a Gαo pathway to inhibit neurotransmitter release from GABAergic motor neurons that synapse onto ventral body wall muscles. Extrasynaptic activation of SER-2 facilitates ventral body wall muscle contraction, contributing to the tight ventral turn that allows the animal to navigate away from a threatening stimulus. Tyramine temporally coordinates the different phases of the escape response through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynaptic activation of the slow-acting metabotropic receptor, SER-2. Our studies show, at the level of single cells, how a sensory input recruits the action of a monoamine to change neural circuit properties and orchestrate a compound motor sequence.
|
| 巻・号 |
11(4)
|
| ページ |
e1001529
|
| 公開日 |
2013-1-1
|
| DOI |
10.1371/journal.pbio.1001529
|
| PII |
PBIOLOGY-D-12-03108
|
| PMID |
23565061
|
| PMC |
PMC3614513
|
| MeSH |
Aldicarb / pharmacology
Animals
Caenorhabditis elegans / cytology
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / metabolism
Cholinesterase Inhibitors / pharmacology
Escape Reaction / physiology*
GABAergic Neurons / metabolism
GTP-Binding Protein alpha Subunits, Gi-Go / genetics
GTP-Binding Protein alpha Subunits, Gi-Go / metabolism
Motor Neurons / metabolism
Muscle Contraction
Neuromuscular Junction / drug effects
Neuromuscular Junction / physiology
Neurotransmitter Agents / pharmacology
Neurotransmitter Agents / physiology*
Receptors, Biogenic Amine / genetics
Receptors, Biogenic Amine / metabolism
Sequence Deletion
Synaptic Transmission
Tyramine / pharmacology
Tyramine / physiology*
|
| IF |
7.076
|
| 引用数 |
56
|
|
WOS 分野
|
BIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 線虫 |
tm1815
tm2913 |
