論文 - 詳細
| RRC ID | 45961 |
|---|---|
| 著者 | Donnelly JL, Clark CM, Leifer AM, Pirri JK, Haburcak M, Francis MM, Samuel AD, Alkema MJ. |
| タイトル | Monoaminergic orchestration of motor programs in a complex C. elegans behavior. |
| ジャーナル | PLoS Biol |
| Abstract |
Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and turns to change its direction of locomotion. We show that the tyramine receptor SER-2 acts through a Gαo pathway to inhibit neurotransmitter release from GABAergic motor neurons that synapse onto ventral body wall muscles. Extrasynaptic activation of SER-2 facilitates ventral body wall muscle contraction, contributing to the tight ventral turn that allows the animal to navigate away from a threatening stimulus. Tyramine temporally coordinates the different phases of the escape response through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynaptic activation of the slow-acting metabotropic receptor, SER-2. Our studies show, at the level of single cells, how a sensory input recruits the action of a monoamine to change neural circuit properties and orchestrate a compound motor sequence. |
| 巻・号 | 11(4) |
| ページ | e1001529 |
| 公開日 | 2013-1-1 |
| DOI | 10.1371/journal.pbio.1001529 |
| PII | PBIOLOGY-D-12-03108 |
| PMID | 23565061 |
| PMC | PMC3614513 |
| MeSH | Aldicarb / pharmacology Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Cholinesterase Inhibitors / pharmacology Escape Reaction / physiology* GABAergic Neurons / metabolism GTP-Binding Protein alpha Subunits, Gi-Go / genetics GTP-Binding Protein alpha Subunits, Gi-Go / metabolism Motor Neurons / metabolism Muscle Contraction Neuromuscular Junction / drug effects Neuromuscular Junction / physiology Neurotransmitter Agents / pharmacology Neurotransmitter Agents / physiology* Receptors, Biogenic Amine / genetics Receptors, Biogenic Amine / metabolism Sequence Deletion Synaptic Transmission Tyramine / pharmacology Tyramine / physiology* |
| IF | 7.076 |
| 引用数 | 56 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1815 tm2913 |