RRC ID 46003
Author Kaul TK, Reis Rodrigues P, Ogungbe IV, Kapahi P, Gill MS.
Title Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
Journal PLoS One
Abstract The dauer larva is a specialized dispersal stage in the nematode Caenorhabditis elegans that allows the animal to survive starvation for an extended period of time. The dauer does not feed, but uses chemosensation to identify new food sources and to determine whether to resume reproductive growth. Bacteria produce food signals that promote recovery of the dauer larva, but the chemical identities of these signals remain poorly defined. We find that bacterial fatty acids in the environment augment recovery from the dauer stage under permissive conditions. The effect of increased fatty acids on different dauer constitutive mutants indicates a role for insulin peptide secretion in coordinating recovery from the dauer stage in response to fatty acids. These data suggest that worms can sense the presence of fatty acids in the environment and that elevated levels can promote recovery from dauer arrest. This may be important in the natural environment where the dauer larva needs to determine whether the environment is appropriate to support reproductive growth following dauer exit.
Volume 9(1)
Pages e86979
Published 2014-1-1
DOI 10.1371/journal.pone.0086979
PII PONE-D-13-35806
PMID 24475206
PMC PMC3901721
MeSH Animals Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Escherichia coli K12 / chemistry Escherichia coli K12 / metabolism Fatty Acids / chemistry* Fatty Acids / metabolism Larva / growth & development Larva / metabolism Olfactory Perception / physiology* Signal Transduction Smell / physiology* Starvation / metabolism
IF 2.74
Times Cited 9
C.elegans tm2416 tm2308