Reference - Detail
| RRC ID | 46043 |
|---|---|
| Author | Lee JY, Kim C, Kim J, Park C. |
| Title | DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state. |
| Journal | Gene |
| Abstract |
Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan. |
| Volume | 524(2) |
| Pages | 373-6 |
| Published | 2013-7-25 |
| DOI | 10.1016/j.gene.2013.04.032 |
| PII | S0378-1119(13)00484-8 |
| PMID | 23624124 |
| MeSH | Aldehyde Oxidoreductases / genetics Aldehyde Oxidoreductases / metabolism* Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / metabolism Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Enzyme Activation Food Deprivation Forkhead Transcription Factors Gene Expression Regulation, Enzymologic* Glyoxal / pharmacology Gonads / drug effects Gonads / metabolism Oxidative Stress Survival Analysis Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic |
| IF | 2.984 |
| Times Cited | 6 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm918 tm1346 |