論文 - 詳細
| RRC ID | 46085 |
|---|---|
| 著者 | Matsuura T, Miura H, Nishino A. |
| タイトル | Inhibition of gustatory plasticity due to acute nicotine exposure in the nematode Caenorhabditis elegans. |
| ジャーナル | Neurosci Res |
| Abstract |
The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the response of N2 nematodes pre-exposed to NaCl without nicotine was significantly lower than that of mock-conditioned nematodes. These results indicate that gustatory plasticity is inhibited by acute nicotine exposure. Inhibition of gustatory plasticity was observed when cat-2 mutants with a defect in dopamine biosynthesis were pre-exposed to NaCl with 3.0mM nicotine. Acute nicotine exposure did not cause inhibition of gustatory plasticity in bas-1 mutants, which had defects in both serotonin and dopamine secretion, and tph-1 mutants, which had a defect in serotonin secretion only. However, inhibition of gustatory plasticity was observed when bas-1 and tph-1 mutants were maintained on a growth plate that included serotonin. These results suggest that serotonin signaling plays an essential role in the modulation of the acute effects of nicotine. |
| 巻・号 | 77(3) |
| ページ | 155-61 |
| 公開日 | 2013-11-1 |
| DOI | 10.1016/j.neures.2013.09.001 |
| PII | S0168-0102(13)00198-3 |
| PMID | 24025430 |
| MeSH | Animals Caenorhabditis elegans Inhibition, Psychological* Learning / drug effects* Locomotion / drug effects Nicotine / toxicity* Nicotinic Agonists / toxicity* Serotonin / metabolism* Serotonin / pharmacology Taste / physiology |
| IF | 2.645 |
| 引用数 | 9 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm351 |