| RRC ID |
46085
|
| 著者 |
Matsuura T, Miura H, Nishino A.
|
| タイトル |
Inhibition of gustatory plasticity due to acute nicotine exposure in the nematode Caenorhabditis elegans.
|
| ジャーナル |
Neurosci Res
|
| Abstract |
The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the response of N2 nematodes pre-exposed to NaCl without nicotine was significantly lower than that of mock-conditioned nematodes. These results indicate that gustatory plasticity is inhibited by acute nicotine exposure. Inhibition of gustatory plasticity was observed when cat-2 mutants with a defect in dopamine biosynthesis were pre-exposed to NaCl with 3.0mM nicotine. Acute nicotine exposure did not cause inhibition of gustatory plasticity in bas-1 mutants, which had defects in both serotonin and dopamine secretion, and tph-1 mutants, which had a defect in serotonin secretion only. However, inhibition of gustatory plasticity was observed when bas-1 and tph-1 mutants were maintained on a growth plate that included serotonin. These results suggest that serotonin signaling plays an essential role in the modulation of the acute effects of nicotine.
|
| 巻・号 |
77(3)
|
| ページ |
155-61
|
| 公開日 |
2013-11-1
|
| DOI |
10.1016/j.neures.2013.09.001
|
| PII |
S0168-0102(13)00198-3
|
| PMID |
24025430
|
| MeSH |
Animals
Caenorhabditis elegans
Inhibition, Psychological*
Learning / drug effects*
Locomotion / drug effects
Nicotine / toxicity*
Nicotinic Agonists / toxicity*
Serotonin / metabolism*
Serotonin / pharmacology
Taste / physiology
|
| IF |
2.645
|
| 引用数 |
9
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| 線虫 |
tm351 |
