RRC ID 46096
著者 Goehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW.
タイトル Polarization of PAR proteins by advective triggering of a pattern-forming system.
ジャーナル Science
Abstract In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The physical mechanisms by which stable asymmetric PAR distributions arise from transient cortical flows remain unclear. We present evidence that PAR polarity arises from coupling of advective transport by the flowing cell cortex to a multistable PAR reaction-diffusion system. By inducing transient PAR segregation, advection serves as a mechanical trigger for the formation of a PAR pattern within an otherwise stably unpolarized system. We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems.
巻・号 334(6059)
ページ 1137-41
公開日 2011-11-25
DOI 10.1126/science.1208619
PII science.1208619
PMID 22021673
MeSH Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Polarity* Cytoplasm / metabolism Diffusion Embryo, Nonmammalian / metabolism Embryo, Nonmammalian / physiology* Embryonic Development Protein Serine-Threonine Kinases Protein Transport
IF 41.846
引用数 145
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm1425