論文 - 詳細
| RRC ID | 46096 |
|---|---|
| 著者 | Goehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW. |
| タイトル | Polarization of PAR proteins by advective triggering of a pattern-forming system. |
| ジャーナル | Science |
| Abstract |
In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The physical mechanisms by which stable asymmetric PAR distributions arise from transient cortical flows remain unclear. We present evidence that PAR polarity arises from coupling of advective transport by the flowing cell cortex to a multistable PAR reaction-diffusion system. By inducing transient PAR segregation, advection serves as a mechanical trigger for the formation of a PAR pattern within an otherwise stably unpolarized system. We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems. |
| 巻・号 | 334(6059) |
| ページ | 1137-41 |
| 公開日 | 2011-11-25 |
| DOI | 10.1126/science.1208619 |
| PII | science.1208619 |
| PMID | 22021673 |
| MeSH | Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Polarity* Cytoplasm / metabolism Diffusion Embryo, Nonmammalian / metabolism Embryo, Nonmammalian / physiology* Embryonic Development Protein Serine-Threonine Kinases Protein Transport |
| IF | 41.846 |
| 引用数 | 145 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1425 |