論文 - 詳細
| RRC ID | 46104 |
|---|---|
| 著者 | Hahm JH, Kim S, Paik YK. |
| タイトル | GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans. |
| ジャーナル | Aging Cell |
| Abstract |
Innate immune responses to pathogens are governed by the nervous system. Here, we investigated the molecular mechanism underlying innate immunity in Caenorhabditis elegans against Escherichia coli OP50, a standard laboratory C. elegans food. Longevity was compared in worms fed live or UV-killed OP50 at low or high density food condition (HDF). Expression of the antimicrobial gene lys-8 was approximately 5-fold higher in worms fed live OP50, suggesting activation of innate immunity upon recognition of OP50 metabolites. Lifespan was extended and SOD-3 mRNA levels were increased in gpa-9-overexpressing gpa-9XS worms under HDF in association with robust induction of insulin/IGF-1 signaling (IIS). Expression of ins-7 and daf-28 that control lys-8 expression was reduced in gpa-9XS, indicating that GPA-9-mediated immunity is due in part to ins-7 and daf-28 downregulation. Our results suggest that OP50 metabolites in amphid neurons elicit innate immunity through the IIS pathway, and identify GPA-9 as a novel regulator of both the immune system and aging in C. elegans. |
| 巻・号 | 10(2) |
| ページ | 208-19 |
| 公開日 | 2011-4-1 |
| DOI | 10.1111/j.1474-9726.2010.00655.x |
| PMID | 21108728 |
| MeSH | Aging Animals Caenorhabditis elegans / immunology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / immunology* Diet* Escherichia coli / immunology* Escherichia coli / pathogenicity GTP-Binding Protein alpha Subunits / genetics GTP-Binding Protein alpha Subunits / immunology* Immunity, Innate* Insulin / immunology Insulin-Like Growth Factor I / immunology Signal Transduction / immunology |
| IF | 7.238 |
| 引用数 | 12 |
| WOS 分野 | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1907 |