論文 - 詳細
| RRC ID | 46114 |
|---|---|
| 著者 | Noble T, Stieglitz J, Srinivasan S. |
| タイトル | An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. |
| ジャーナル | Cell Metab |
| Abstract |
Serotonin (5-hydroxytryptamine, 5-HT) is an ancient and conserved neuromodulator of energy balance. Despite its importance, the neural circuits and molecular mechanisms underlying 5-HT-mediated control of body fat remain poorly understood. Here, we decipher the serotonergic neural circuit for body fat loss in C. elegans and show that the effects of 5-HT require signaling from octopamine, the invertebrate analog of adrenaline, to sustain body fat loss. Our results provide a potential molecular explanation for the long-observed potent effects of combined serotonergic and adrenergic weight loss drugs. In metabolic tissues, we find that the conserved regulatory adipocyte triglyceride lipase ATGL-1 drives serotonergic fat loss. We show that the serotonergic chloride channel MOD-1 relays a long-range endocrine signal from C. elegans body cavity neurons to control distal ATGL-1 function, via the nuclear receptor NHR-76. Our findings establish a conserved neuroendocrine axis operated by neural serotonergic and adrenergic-like signaling to regulate body fat. |
| 巻・号 | 18(5) |
| ページ | 672-84 |
| 公開日 | 2013-11-5 |
| DOI | 10.1016/j.cmet.2013.09.007 |
| PII | S1550-4131(13)00376-8 |
| PMID | 24120942 |
| PMC | PMC3882029 |
| MeSH | Adipose Tissue / metabolism* Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Chloride Channels / metabolism Endocrine System / metabolism* Lipolysis Models, Biological Neurons / metabolism* Octopamine / metabolism* Olfactory Nerve / cytology Olfactory Nerve / metabolism Serotonin / metabolism* Signal Transduction* Transcription, Genetic / drug effects |
| IF | 21.567 |
| 引用数 | 44 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2146 tm1846 |