RRC ID 46151
著者 Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z.
タイトル A whole-organism screen identifies new regulators of fat storage.
ジャーナル Nat Chem Biol
Abstract The regulation of energy homeostasis integrates diverse biological processes ranging from behavior to metabolism and is linked fundamentally to numerous disease states. To identify new molecules that can bypass homeostatic compensatory mechanisms of energy balance in intact animals, we screened for small-molecule modulators of Caenorhabditis elegans fat content. We report on several molecules that modulate fat storage without obvious deleterious effects on feeding, growth and reproduction. A subset of these compounds also altered fat storage in mammalian and insect cell culture. We found that one of the newly identified compounds exerts its effects in C. elegans through a pathway that requires previously undescribed functions of an AMP-activated kinase catalytic subunit and a transcription factor previously unassociated with fat regulation. Thus, our strategy identifies small molecules that are effective within the context of intact animals and reveals relationships between new pathways that operate across phyla to influence energy homeostasis.
巻・号 7(4)
ページ 206-13
公開日 2011-4-1
DOI 10.1038/nchembio.534
PII nchembio.534
PMID 21390037
PMC PMC3076723
MeSH AMP-Activated Protein Kinases / metabolism Adipose Tissue / metabolism Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Catalysis Energy Metabolism Fats / metabolism* Homeostasis Lipid Metabolism*
IF 12.587
引用数 45
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm1944