論文 - 詳細
| RRC ID | 46151 |
|---|---|
| 著者 | Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. |
| タイトル | A whole-organism screen identifies new regulators of fat storage. |
| ジャーナル | Nat Chem Biol |
| Abstract |
The regulation of energy homeostasis integrates diverse biological processes ranging from behavior to metabolism and is linked fundamentally to numerous disease states. To identify new molecules that can bypass homeostatic compensatory mechanisms of energy balance in intact animals, we screened for small-molecule modulators of Caenorhabditis elegans fat content. We report on several molecules that modulate fat storage without obvious deleterious effects on feeding, growth and reproduction. A subset of these compounds also altered fat storage in mammalian and insect cell culture. We found that one of the newly identified compounds exerts its effects in C. elegans through a pathway that requires previously undescribed functions of an AMP-activated kinase catalytic subunit and a transcription factor previously unassociated with fat regulation. Thus, our strategy identifies small molecules that are effective within the context of intact animals and reveals relationships between new pathways that operate across phyla to influence energy homeostasis. |
| 巻・号 | 7(4) |
| ページ | 206-13 |
| 公開日 | 2011-4-1 |
| DOI | 10.1038/nchembio.534 |
| PII | nchembio.534 |
| PMID | 21390037 |
| PMC | PMC3076723 |
| MeSH | AMP-Activated Protein Kinases / metabolism Adipose Tissue / metabolism Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Catalysis Energy Metabolism Fats / metabolism* Homeostasis Lipid Metabolism* |
| IF | 12.587 |
| 引用数 | 45 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1944 |