論文 - 詳細
| RRC ID | 46152 |
|---|---|
| 著者 | Li W, Kang L, Piggott BJ, Feng Z, Xu XZ. |
| タイトル | The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Most animals can distinguish two distinct types of touch stimuli: gentle (innocuous) and harsh (noxious/painful) touch, however, the underlying mechanisms are not well understood. Caenorhabditis elegans is a useful model for the study of gentle touch sensation. However, little is known about harsh touch sensation in this organism. Here we characterize harsh touch sensation in C. elegans. We show that C. elegans exhibits differential behavioural responses to harsh touch and gentle touch. Laser ablations identify distinct sets of sensory neurons and interneurons required for harsh touch sensation at different body segments. Optogenetic stimulation of the circuitry can drive behaviour. Patch-clamp recordings reveal that TRP family and amiloride-sensitive Na(+) channels mediate touch-evoked currents in different sensory neurons. Our work identifies the neural circuits and characterizes the sensory channels mediating harsh touch sensation in C. elegans, establishing it as a genetic model for studying this sensory modality. |
| 巻・号 | 2 |
| ページ | 315 |
| 公開日 | 2011-1-1 |
| DOI | 10.1038/ncomms1308 |
| PII | ncomms1308 |
| PMID | 21587232 |
| PMC | PMC3098610 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Interneurons / physiology* Sensory Receptor Cells / physiology* Sodium Channels / genetics Sodium Channels / metabolism* Touch Transient Receptor Potential Channels / genetics Transient Receptor Potential Channels / metabolism* |
| IF | 12.121 |
| 引用数 | 71 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1552 |