| RRC ID |
46175
|
| 著者 |
Ritter AD, Shen Y, Fuxman Bass J, Jeyaraj S, Deplancke B, Mukhopadhyay A, Xu J, Driscoll M, Tissenbaum HA, Walhout AJ.
|
| タイトル |
Complex expression dynamics and robustness in C. elegans insulin networks.
|
| ジャーナル |
Genome Res
|
| Abstract |
Gene families expand by gene duplication, and resulting paralogs diverge through mutation. Functional diversification can include neofunctionalization as well as subfunctionalization of ancestral functions. In addition, redundancy in which multiple genes fulfill overlapping functions is often maintained. Here, we use the family of 40 Caenorhabditis elegans insulins to gain insight into the balance between specificity and redundancy. The insulin/insulin-like growth factor (IIS) pathway comprises a single receptor, DAF-2. To date, no single insulin-like peptide recapitulates all DAF-2-associated phenotypes, likely due to redundancy between insulin-like genes. To provide a first-level annotation of potential patterns of redundancy, we comprehensively delineate the spatiotemporal and conditional expression of all 40 insulins in living animals. We observe extensive dynamics in expression that can explain the lack of simple patterns of pairwise redundancy. We propose a model in which gene families evolve to attain differential alliances in different tissues and in response to a range of environmental stresses.
|
| 巻・号 |
23(6)
|
| ページ |
954-65
|
| 公開日 |
2013-6-1
|
| DOI |
10.1101/gr.150466.112
|
| PII |
gr.150466.112
|
| PMID |
23539137
|
| PMC |
PMC3668363
|
| MeSH |
Animals
Caenorhabditis elegans / genetics*
Caenorhabditis elegans / metabolism*
Cluster Analysis
Gene Expression Profiling
Gene Expression Regulation*
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Insulin / genetics*
Insulin / metabolism*
RNA Interference
Signal Transduction*
|
| IF |
11.093
|
| 引用数 |
47
|
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
GENETICS & HEREDITY
|
| リソース情報 |
| 線虫 |
tm1907
tm4144 |
