Reference - Detail
| RRC ID | 46181 |
|---|---|
| Author | Rui Q, Zhao Y, Wu Q, Tang M, Wang D. |
| Title | Biosafety assessment of titanium dioxide nanoparticles in acutely exposed nematode Caenorhabditis elegans with mutations of genes required for oxidative stress or stress response. |
| Journal | Chemosphere |
| Abstract |
We used Caenorhabditis elegans to investigate whether acute exposure to TiO2-NPs at the concentration of 20 μg L(-1) reflecting predicted environmental relevant concentration and 25 mg L(-1) reflecting concentration in food can cause toxicity on nematodes with mutations of susceptible genes. Among examined mutants associated with oxidative stress and stress response, we found that genes of sod-2, sod-3, mtl-2, and hsp-16.48 might be susceptible for TiO2-NPs toxicity. Mutations of these genes altered functions of both possible primary and secondary targeted organs in nematodes exposed to 25 mg L(-1) of TiO2-NPs for 24-h. Mutations of these genes caused similar expression patterns of genes required for oxidative stress in TiO2-NPs exposed mutant nematodes, implying their similar mechanisms to form the susceptible property. Nevertheless, acute exposure to 20 μg L(-1) of TiO2-NPs for 24-h and 25 mg L(-1) of TiO2-NPs for 0.48-h or 5.71-h did not influence functions of both possible primary and secondary targeted organs in sod-2, sod-3, mtl-2, and hsp-16.48 mutants. Therefore, our results suggest the relatively safe property of acute exposure to TiO2-NPs with certain durations at predicted environmental relevant concentrations or concentrations comparable to those in food in nematodes with mutations of some susceptible genes. |
| Volume | 93(10) |
| Pages | 2289-96 |
| Published | 2013-11-1 |
| DOI | 10.1016/j.chemosphere.2013.08.007 |
| PII | S0045-6535(13)01087-4 |
| PMID | 24001673 |
| MeSH | Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / genetics Mutation Nanoparticles / toxicity* Oxidative Stress / genetics* Risk Assessment Titanium / toxicity* Toxicity Tests, Acute |
| IF | 5.778 |
| Times Cited | 49 |
| WOS Category | ENVIRONMENTAL SCIENCES |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | NA |