RRC ID 46199
著者 Smith ES, Martinez-Velazquez L, Ringstad N.
タイトル A chemoreceptor that detects molecular carbon dioxide.
ジャーナル J Biol Chem
Abstract Animals from diverse phyla possess neurons that are activated by the product of aerobic respiration, CO2. It has long been thought that such neurons primarily detect the CO2 metabolites protons and bicarbonate. We have determined the chemical tuning of isolated CO2 chemosensory BAG neurons of the nematode Caenorhabditis elegans. We show that BAG neurons are principally tuned to detect molecular CO2, although they can be activated by acid stimuli. One component of the BAG transduction pathway, the receptor-type guanylate cyclase GCY-9, suffices to confer cellular sensitivity to both molecular CO2 and acid, indicating that it is a bifunctional chemoreceptor. We speculate that in other animals, receptors similarly capable of detecting molecular CO2 might mediate effects of CO2 on neural circuits and behavior.
巻・号 288(52)
ページ 37071-81
公開日 2013-12-27
DOI 10.1074/jbc.M113.517367
PII S0021-9258(20)55282-4
PMID 24240097
PMC PMC3873563
MeSH Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carbon Dioxide / metabolism* Carbonic Acid / metabolism* Cells, Cultured Chemoreceptor Cells / cytology Chemoreceptor Cells / metabolism* Receptors, Guanylate Cyclase-Coupled / genetics Receptors, Guanylate Cyclase-Coupled / metabolism* Signal Transduction / physiology*
IF 4.238
引用数 30
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm2816