論文 - 詳細
| RRC ID | 46222 |
|---|---|
| 著者 | Viswanathan M, Tissenbaum HA. |
| タイトル | C. elegans sirtuins. |
| ジャーナル | Methods Mol Biol |
| Abstract |
The nematode Caenorhabditis elegans (C. elegans) has four Sir2 paralogs, sir-2.1, sir-2.2, sir-2.3, and sir-2.4. Thus far, most of the research tools to study worm sirtuins have been developed for sir-2.1, due to its homology to yeast SIR2 and human SIRT1. Here, we have compiled a listing of the currently available strains (including both loss-of-function alleles and transgenics), antibodies, and RNAi constructs relevant to studies on all C. elegans sirtuin family members. We also describe the methods used in the analysis of C. elegans sirtuin function, including life span analysis, various stress-resistance assays, and fat content analysis and provide an overview of all phenotypic data relevant to C. elegans sir-2.1. |
| 巻・号 | 1077 |
| ページ | 39-56 |
| 公開日 | 2013-1-1 |
| DOI | 10.1007/978-1-62703-637-5_3 |
| PMID | 24014398 |
| MeSH | Adipocytes / cytology Adipocytes / metabolism Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Humans Longevity / physiology* Oxidative Stress Sirtuins / metabolism* |
| 引用数 | 3 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | NA |