論文 - 詳細
| RRC ID | 46240 |
|---|---|
| 著者 | Wu YE, Huo L, Maeder CI, Feng W, Shen K. |
| タイトル | The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapses. |
| ジャーナル | Neuron |
| Abstract |
The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynaptic protein transport and deposition to achieve proper distribution of synaptic material. Here we show that SV and AZ proteins exhibit extensive cotransport and undergo frequent pauses. At the axonal and synaptic pause sites, the balance between the capture and dissociation of mobile transport packets determines the extent of presynaptic assembly. The small G protein ARL-8 inhibits assembly by promoting dissociation, while a JNK kinase pathway and AZ assembly proteins inhibit dissociation. Furthermore, ARL-8 directly binds to the UNC-104/KIF1A motor to limit the capture efficiency. Together, molecular regulation of the dichotomy between axonal trafficking and local assembly controls vital aspects of synapse formation and maintenance. |
| 巻・号 | 78(6) |
| ページ | 994-1011 |
| 公開日 | 2013-6-19 |
| DOI | 10.1016/j.neuron.2013.04.035 |
| PII | S0896-6273(13)00366-8 |
| PMID | 23727120 |
| PMC | PMC3898717 |
| MeSH | Animals Animals, Genetically Modified Axons / metabolism Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* GTP Phosphohydrolases / genetics GTP Phosphohydrolases / metabolism* MAP Kinase Signaling System / physiology Presynaptic Terminals / metabolism* Protein Transport / physiology Synapses / genetics Synapses / metabolism* |
| IF | 14.415 |
| 引用数 | 65 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2388 tm1125 |