| RRC ID |
46256
|
| 著者 |
Smith CJ, O'Brien T, Chatzigeorgiou M, Spencer WC, Feingold-Link E, Husson SJ, Hori S, Mitani S, Gottschalk A, Schafer WR, Miller DM 3rd.
|
| タイトル |
Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization.
|
| ジャーナル |
Neuron
|
| Abstract |
Sensory neurons adopt distinct morphologies and functional modalities to mediate responses to specific stimuli. Transcription factors and their downstream effectors orchestrate this outcome but are incompletely defined. Here, we show that different classes of mechanosensory neurons in C. elegans are distinguished by the combined action of the transcription factors MEC-3, AHR-1, and ZAG-1. Low levels of MEC-3 specify the elaborate branching pattern of PVD nociceptors, whereas high MEC-3 is correlated with the simple morphology of AVM and PVM touch neurons. AHR-1 specifies AVM touch neuron fate by elevating MEC-3 while simultaneously blocking expression of nociceptive genes such as the MEC-3 target, the claudin-like membrane protein HPO-30, that promotes the complex dendritic branching pattern of PVD. ZAG-1 exercises a parallel role to prevent PVM from adopting the PVD fate. The conserved dendritic branching function of the Drosophila AHR-1 homolog, Spineless, argues for similar pathways in mammals.
|
| 巻・号 |
79(2)
|
| ページ |
266-80
|
| 公開日 |
2013-7-24
|
| DOI |
10.1016/j.neuron.2013.05.009
|
| PII |
S0896-6273(13)00402-9
|
| PMID |
23889932
|
| PMC |
PMC3795438
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Dendrites / physiology*
Dendritic Spines / physiology
Neurogenesis / physiology*
Sensory Receptor Cells / physiology*
Transcription Factors / physiology*
Transcription, Genetic / physiology*
|
| IF |
14.415
|
| 引用数 |
51
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| 線虫 |
tm5213 |
