論文 - 詳細
| RRC ID | 46273 |
|---|---|
| 著者 | Boulias K, Horvitz HR. |
| タイトル | The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. |
| ジャーナル | Cell Metab |
| Abstract |
The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. Here we analyze microRNA function in C. elegans aging and show that the microRNA mir-71 functions to mediate the effects of germ cell loss on life span. mir-71 is required for the life span extension caused by germline removal, and overexpression of mir-71 further extends the life span of animals lacking germ cells. mir-71 functions in the nervous system to facilitate the localization and transcriptional activity of DAF-16 in the intestine. Our findings reveal a microRNA-dependent mechanism of life span regulation by the germline and indicate that signaling among the gonad, the nervous system, and the intestine coordinates the life span of the entire organism. |
| 巻・号 | 15(4) |
| ページ | 439-50 |
| 公開日 | 2012-4-4 |
| DOI | 10.1016/j.cmet.2012.02.014 |
| PII | S1550-4131(12)00096-4 |
| PMID | 22482727 |
| PMC | PMC3344382 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Lineage / genetics Forkhead Transcription Factors Gene Expression Regulation, Developmental Germ Cells / cytology Germ Cells / metabolism* Intestinal Mucosa / metabolism Intestines / cytology Longevity MicroRNAs / genetics MicroRNAs / metabolism* Models, Biological Neurons / cytology Neurons / metabolism* Protein Transport Stress, Physiological / genetics Transcription Factors / metabolism* Transcription, Genetic |
| IF | 21.567 |
| 引用数 | 117 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1452 |