| RRC ID |
46274
|
| Author |
Brown AE, Yemini EI, Grundy LJ, Jucikas T, Schafer WR.
|
| Title |
A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion.
|
| Journal |
Proc Natl Acad Sci U S A
|
| Abstract |
Visible phenotypes based on locomotion and posture have played a critical role in understanding the molecular basis of behavior and development in Caenorhabditis elegans and other model organisms. However, it is not known whether these human-defined features capture the most important aspects of behavior for phenotypic comparison or whether they are sufficient to discover new behaviors. Here we show that four basic shapes, or eigenworms, previously described for wild-type worms, also capture mutant shapes, and that this representation can be used to build a dictionary of repetitive behavioral motifs in an unbiased way. By measuring the distance between each individual's behavior and the elements in the motif dictionary, we create a fingerprint that can be used to compare mutants to wild type and to each other. This analysis has revealed phenotypes not previously detected by real-time observation and has allowed clustering of mutants into related groups. Behavioral motifs provide a compact and intuitive representation of behavioral phenotypes.
|
| Volume |
110(2)
|
| Pages |
791-6
|
| Published |
2013-1-8
|
| DOI |
10.1073/pnas.1211447110
|
| PII |
1211447110
|
| PMID |
23267063
|
| PMC |
PMC3545781
|
| MeSH |
Animals
Behavior, Animal / classification
Behavior, Animal / physiology*
Caenorhabditis elegans / classification
Caenorhabditis elegans / genetics*
Caenorhabditis elegans / physiology
Genes / genetics*
Genetics, Behavioral / methods
Locomotion / genetics*
Locomotion / physiology
Models, Biological*
Pattern Recognition, Automated / methods
Phenotype*
Posture / physiology
Reproducibility of Results
|
| IF |
9.412
|
| Times Cited |
101
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| C.elegans |
tm2173
tm3085
tm3092
tm1392
tm2654
tm1325
tm1846
tm2146 |
