RRC ID 46302
著者 Correa P, LeBoeuf B, García LR.
タイトル C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior.
ジャーナル PLoS Genet
Abstract Caenorhabditis elegans male copulation requires coordinated temporal-spatial execution of different motor outputs. During mating, a cloacal circuit consisting of cholinergic sensory-motor neurons and sex muscles maintains the male's position and executes copulatory spicule thrusts at his mate's vulva. However, distinct signaling mechanisms that delimit these behaviors to their proper context are unclear. We found that dopamine (DA) signaling directs copulatory spicule insertion attempts to the hermaphrodite vulva by dampening spurious stimulus-independent sex muscle contractions. From pharmacology and genetic analyses, DA antagonizes stimulatory ACh signaling via the D2-like receptors, DOP-2 and DOP-3, and Gα(o/i) proteins, GOA-1 and GPA-7. Calcium imaging and optogenetics suggest that heightened DA-expressing ray neuron activities coincide with the cholinergic cloacal ganglia function during spicule insertion attempts. D2-like receptor signaling also attenuates the excitability of additional mating circuits to reduce the duration of mating attempts with unproductive and/or inappropriate partners. This suggests that, during wild-type mating, simultaneous DA-ACh signaling modulates the activity threshold of repetitive motor programs, thus confining the behavior to the proper situational context.
巻・号 8(11)
ページ e1003015
公開日 2012-1-1
DOI 10.1371/journal.pgen.1003015
PII PGENETICS-D-12-00652
PMID 23166505
PMC PMC3499252
MeSH Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Caenorhabditis elegans Proteins* / physiology Cholinergic Antagonists / administration & dosage Cholinergic Neurons / drug effects Copulation / physiology Disorders of Sex Development Dopamine* / genetics Dopamine* / metabolism Dopamine* / physiology Female Male Muscle Contraction / genetics Muscle Contraction / physiology Receptors, Cholinergic* / metabolism Receptors, Cholinergic* / physiology Receptors, Dopamine D2* / genetics Receptors, Dopamine D2* / metabolism Receptors, Dopamine D2* / physiology Sexual Behavior, Animal Signal Transduction / drug effects Vulva / physiology
IF 5.175
引用数 18
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1392