| RRC ID |
46306
|
| Author |
Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K.
|
| Title |
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
|
| Journal |
Cell Metab
|
| Abstract |
Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.
|
| Volume |
16(1)
|
| Pages |
113-21
|
| Published |
2012-7-3
|
| DOI |
10.1016/j.cmet.2012.05.014
|
| PII |
S1550-4131(12)00239-2
|
| PMID |
22768843
|
| PMC |
PMC3413480
|
| MeSH |
AMP-Activated Protein Kinases
Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism
Caenorhabditis elegans / cytology
Caenorhabditis elegans / enzymology*
Caenorhabditis elegans / physiology
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Cells, Cultured
Chemoreceptor Cells / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism
Feeding Behavior*
Gastrointestinal Motility
Glutamic Acid / metabolism*
Hippocampus / cytology
Pharynx / innervation
Pharynx / metabolism
Pharynx / physiology
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Rats
Receptors, Serotonin / metabolism
Serotonergic Neurons / enzymology
Serotonergic Neurons / metabolism
Serotonin / metabolism
Synaptic Transmission*
|
| IF |
21.567
|
| Times Cited |
37
|
|
WOS Category
|
ENDOCRINOLOGY & METABOLISM
CELL BIOLOGY
|
| Resource |
| C.elegans |
tm2877
tm2654
tm1944
tm1325 |
