RRC ID 46312
著者 Ohnishi N, Kuhara A, Nakamura F, Okochi Y, Mori I.
タイトル Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans.
ジャーナル EMBO J
Abstract In complex neural circuits of the brain, massive information is processed with neuronal communication through synaptic transmissions. It is thus fundamental to delineate information flows encoded by various kinds of transmissions. Here, we show that glutamate signals from two distinct sensory neurons bidirectionally affect the same postsynaptic interneuron, thereby producing the opposite behaviours. EAT-4/VGLUT (vesicular glutamate transporter)-dependent glutamate signals from AFD thermosensory neurons inhibit the postsynaptic AIY interneurons through activation of GLC-3/GluCl inhibitory glutamate receptor and behaviourally drive migration towards colder temperature. By contrast, EAT-4-dependent glutamate signals from AWC thermosensory neurons stimulate the AIY neurons to induce migration towards warmer temperature. Alteration of the strength of AFD and AWC signals led to significant changes of AIY activity, resulting in drastic modulation of behaviour. We thus provide an important insight on information processing, in which two glutamate transmissions encoding opposite information flows regulate neural activities to produce a large spectrum of behavioural outputs.
巻・号 30(7)
ページ 1376-88
公開日 2011-4-6
DOI 10.1038/emboj.2011.13
PII emboj201113
PMID 21304490
PMC PMC3094115
MeSH Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Glutamic Acid / metabolism* Locomotion* Neurotransmitter Agents / metabolism* Receptors, Glutamate / metabolism Stress, Physiological* Synaptic Transmission* Temperature Vesicular Glutamate Transport Proteins
IF 9.889
引用数 47
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm1811