RRC ID |
46370
|
著者 |
Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, Ishihara T.
|
タイトル |
Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway.
|
ジャーナル |
Cell Rep
|
Abstract |
The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of odor-evoked Ca(2+) responses in olfactory neurons, and this attenuation is prolonged in the TIR-1/JNK-1-pathway mutant animals. We also found that a pair of neurons in which the pathway functions is required for the acceleration of forgetting, but not for sensation or adaptation, in wild-type animals. In addition, the neurosecretion from these cells is important for the acceleration of forgetting. Therefore, we propose that these neurons accelerate forgetting through the TIR-1/JNK-1 pathway by sending signals that directly or indirectly stimulate forgetting.
|
巻・号 |
3(3)
|
ページ |
808-19
|
公開日 |
2013-3-28
|
DOI |
10.1016/j.celrep.2013.02.019
|
PII |
S2211-1247(13)00095-8
|
PMID |
23523351
|
MeSH |
Adaptation, Physiological / genetics
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Calcium / metabolism
Cytoskeletal Proteins / genetics
Cytoskeletal Proteins / metabolism*
MAP Kinase Signaling System
Memory*
Mitogen-Activated Protein Kinase 8 / metabolism*
Mutation
Neurons / metabolism*
Receptors, G-Protein-Coupled
Smell / genetics
|
IF |
8.109
|
引用数 |
22
|
WOS 分野
|
CELL BIOLOGY
|
リソース情報 |
線虫 |
tm3036 |