RRC ID 46370
著者 Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, Ishihara T.
タイトル Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway.
ジャーナル Cell Rep
Abstract The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of odor-evoked Ca(2+) responses in olfactory neurons, and this attenuation is prolonged in the TIR-1/JNK-1-pathway mutant animals. We also found that a pair of neurons in which the pathway functions is required for the acceleration of forgetting, but not for sensation or adaptation, in wild-type animals. In addition, the neurosecretion from these cells is important for the acceleration of forgetting. Therefore, we propose that these neurons accelerate forgetting through the TIR-1/JNK-1 pathway by sending signals that directly or indirectly stimulate forgetting.
巻・号 3(3)
ページ 808-19
公開日 2013-3-28
DOI 10.1016/j.celrep.2013.02.019
PII S2211-1247(13)00095-8
PMID 23523351
MeSH Adaptation, Physiological / genetics Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Calcium / metabolism Cytoskeletal Proteins / genetics Cytoskeletal Proteins / metabolism* MAP Kinase Signaling System Memory* Mitogen-Activated Protein Kinase 8 / metabolism* Mutation Neurons / metabolism* Receptors, G-Protein-Coupled Smell / genetics
IF 8.109
引用数 22
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm3036