Reference - Detail
| RRC ID | 46387 |
|---|---|
| Author | Knight AJ, Johnson NM, Behm CA. |
| Title | VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes. |
| Journal | PLoS One |
| Abstract |
There is an urgent need to develop new drugs against parasitic nematodes, which are a significant burden on human health and agriculture. Information about the function of essential nematode-specific genes provides insight to key nematode-specific processes that could be targeted with drugs. We have characterized the function of a novel, nematode-specific Caenorhabditis elegans protein, VHA-19, and show that VHA-19 is essential in the germline and, specifically, the oocytes, for the completion of embryogenesis. VHA-19 is also involved in trafficking the oocyte receptor RME-2 to the oocyte plasma membrane and is essential for osmoregulation in the embryo, probably because VHA-19 is required for proper eggshell formation via exocytosis of cortical granules or other essential components of the eggshell. VHA-19 may also have a role in cytokinesis, either directly or as an indirect effect of its role in osmoregulation. Critically, VHA-19 is expressed in the excretory cell in both larvae and adults, suggesting that it may have a role in osmoregulation in C. elegans more generally, probably in trafficking or secretion pathways. This is the first time a role for VHA-19 has been described. |
| Volume | 7(7) |
| Pages | e40317 |
| Published | 2012-1-1 |
| DOI | 10.1371/journal.pone.0040317 |
| PII | PONE-D-12-07050 |
| PMID | 22768351 |
| PMC | PMC3388054 |
| MeSH | Animals Biological Transport / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Membrane / genetics Cell Membrane / metabolism Embryo, Nonmammalian / metabolism* Embryonic Development / physiology* Humans Oocytes / cytology Oocytes / metabolism* Water-Electrolyte Balance / physiology* |
| IF | 2.74 |
| Times Cited | 2 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2205 |