論文 - 詳細
| RRC ID | 46407 |
|---|---|
| 著者 | Meelkop E, Temmerman L, Janssen T, Suetens N, Beets I, Van Rompay L, Shanmugam N, Husson SJ, Schoofs L. |
| タイトル | PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying. |
| ジャーナル | Mol Cell Endocrinol |
| Abstract |
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior. Cell specific rescue experiments show that this pdf mediated behavior is regulated by neurons rather than body wall muscles. We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying. |
| 巻・号 | 361(1-2) |
| ページ | 232-40 |
| 公開日 | 2012-9-25 |
| DOI | 10.1016/j.mce.2012.05.001 |
| PII | S0303-7207(12)00266-3 |
| PMID | 22579613 |
| MeSH | Animals Behavior, Animal / physiology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Gene Knockout Techniques Locomotion / physiology* Mutation / genetics Oviposition / physiology* Receptors, G-Protein-Coupled / metabolism* Signal Transduction* Swimming / physiology |
| IF | 3.871 |
| 引用数 | 22 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1996 tm4393 tm4457 tm4780 |