論文 - 詳細
| RRC ID | 46446 |
|---|---|
| 著者 | Song BM, Faumont S, Lockery S, Avery L. |
| タイトル | Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans. |
| ジャーナル | Elife |
| Abstract |
Familiarity discrimination has a significant impact on the pattern of food intake across species. However, the mechanism by which the recognition memory controls feeding is unclear. Here, we show that the nematode Caenorhabditis elegans forms a memory of particular foods after experience and displays behavioral plasticity, increasing the feeding response when they subsequently recognize the familiar food. We found that recognition of familiar food activates the pair of ADF chemosensory neurons, which subsequently increase serotonin release. The released serotonin activates the feeding response mainly by acting humorally and directly activates SER-7, a type 7 serotonin receptor, in MC motor neurons in the feeding organ. Our data suggest that worms sense the taste and/or smell of novel bacteria, which overrides the stimulatory effect of familiar bacteria on feeding by suppressing the activity of ADF or its upstream neurons. Our study provides insight into the mechanism by which familiarity discrimination alters behavior.DOI:http://dx.doi.org/10.7554/eLife.00329.001. |
| 巻・号 | 2 |
| ページ | e00329 |
| 公開日 | 2013-2-5 |
| DOI | 10.7554/eLife.00329 |
| PII | 00329 |
| PMID | 23390589 |
| PMC | PMC3564447 |
| MeSH | Animals Bacteria / metabolism* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Chemoreceptor Cells / metabolism* Discrimination, Psychological Eating* Feeding Behavior* Food Preferences GTP-Binding Protein alpha Subunits, Gs / metabolism Motor Neurons / metabolism Mutation Pharynx / innervation* Recognition, Psychology* Serotonin / metabolism* Signal Transduction* Smell Taste Time Factors |
| IF | 7.08 |
| 引用数 | 38 |
| WOS 分野 | BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1325 |