RRC ID 46505
Author Bamunusinghe D, Liu Q, Lu X, Oler A, Kozak CA.
Title Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor.
Journal J Virol
Abstract The xenotropic and polytropic mouse leukemia viruses (X-MLVs and P-MLVs, respectively) have different host ranges but use the same functionally polymorphic receptor, XPR1, for entry. Endogenous retroviruses (ERVs) of these 2 gammaretrovirus subtypes are largely segregated in different house mouse subspecies, but both MLV types are found in the classical strains of laboratory mice, which are genetic mosaics of 3 wild mouse subspecies. To describe the subspecies origins of laboratory mouse XP-MLV ERVs and their coevolutionary trajectory with their XPR1 receptor, we screened the house mouse subspecies for known and novel Xpr1 variants and for the individual full-length XP-MLV ERVs found in the sequenced C57BL mouse genome. The 12 X-MLV ERVs predate the origins of laboratory mice; they were all traced to Japanese wild mice and are embedded in the 5% of the laboratory mouse genome derived from the Asian Mus musculus musculus and, in one case, in the <1% derived from M. m. castaneus. While all 31 P-MLV ERVs map to the 95% of the laboratory mouse genome derived from P-MLV-infected M. m. domesticus, no C57BL P-MLV ERVs were found in wild M. m. domesticus. All M. m. domesticus mice carry the fully permissive XPR1 receptor allele, but all of the various restrictive XPR1 receptors, including the X-MLV-restricting laboratory mouse Xpr1(n) and a novel M. m. castaneus allele, originated in X-MLV-infected Asian mice. Thus, P-MLV ERVs show more insertional polymorphism than X-MLVs, and these differences in ERV acquisition and fixation are linked to subspecies-specific and functionally distinct XPR1 receptor variants.
Volume 87(17)
Pages 9845-55
Published 2013-9-1
DOI 10.1128/JVI.01264-13
PII JVI.01264-13
PMID 23824809
PMC PMC3754108
MeSH Alleles Animals Animals, Wild / genetics Animals, Wild / virology Endogenous Retroviruses / isolation & purification Endogenous Retroviruses / physiology* Evolution, Molecular Genetic Variation Host Specificity / genetics* Host Specificity / physiology* Leukemia Virus, Murine / isolation & purification Leukemia Virus, Murine / physiology* Mice / classification Mice / genetics* Mice / virology* Mice, Inbred C57BL Mice, Inbred Strains Proviruses / isolation & purification Proviruses / physiology Receptors, G-Protein-Coupled / genetics* Receptors, G-Protein-Coupled / physiology* Receptors, Virus / genetics* Receptors, Virus / physiology* Species Specificity Terminal Repeat Sequences
IF 4.501
Times Cited 12
DNA material Genomic DNA of mouse: Mus musculus molossinus M.MUS-NJL RBRC00207 male (RDB06977) Mus musculus molossinus STM1 RBRC00265 male (RDB06981) Mus musculus molossinus STM2 RBRC00266 male (RDB06982) Mus musculus molossinus Mol-KOR5/Stm RBRC00428 male (RDB06983) Mus musculus molossinus Mol-KOR7/Stm RBRC00429 male (RDB06984) Mus musculus molossinus Mol-AIZ/Stm RBRC00430 male (RDB06985) Mus musculus molossinus Mol-Mae/Stm RBRC00431 male (RDB06986) Mus musculus spp. KJR/Ms RBRC00655 male (RDB06988) Mus musculus castaneus HMI/Ms RBRC00657 male (RDB06989) Mus musculus musculus MBT/Pas RBRC01164 male (RDB06992) Mus musculus castaneus MYS/Mz RBRC01196 male (RDB06993) Mus musculus musculus Akt/TUA RBRC01238 male (RDB06994) Mus musculus musculus Ast/TUA RBRC01249 male (RDB06995) Mus musculus molossinus MOM RBRC01837 male (RDB06996).