論文 - 詳細
| RRC ID | 46525 |
|---|---|
| 著者 | Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT. |
| タイトル | Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Many animals, including humans, select alternate forms of motion (gaits) to move efficiently in different environments. However, it is unclear whether primitive animals, such as nematodes, also use this strategy. We used a multifaceted approach to study how the nematode Caenorhabditis elegans freely moves into and out of water. We demonstrate that C. elegans uses biogenic amines to switch between distinct crawling and swimming gaits. Dopamine is necessary and sufficient to initiate and maintain crawling after swimming. Serotonin is necessary and sufficient to transition from crawling to swimming and to inhibit a set of crawl-specific behaviors. Further study of locomotory switching in C. elegans and its dependence on biogenic amines may provide insight into how gait transitions are performed in other animals. |
| 巻・号 | 108(42) |
| ページ | 17504-9 |
| 公開日 | 2011-10-18 |
| DOI | 10.1073/pnas.1108673108 |
| PII | 1108673108 |
| PMID | 21969584 |
| PMC | PMC3198358 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal / physiology Biomechanical Phenomena Caenorhabditis elegans / physiology* Dopamine / physiology* Dopaminergic Neurons / physiology Gait / physiology Locomotion / physiology* Serotonergic Neurons / physiology Serotonin / physiology* Signal Transduction / physiology Swimming / physiology Video Recording Viscosity Water |
| IF | 9.412 |
| 引用数 | 71 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1062 tm1392 tm2654 tm2146 tm2104 tm1325 |