論文 - 詳細
RRC ID | 46536 |
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著者 | Xu M, Joo HJ, Paik YK. |
タイトル | Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. |
ジャーナル | J Biol Chem |
Abstract |
The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions. |
巻・号 | 286(32) |
ページ | 28111-8 |
公開日 | 2011-8-12 |
DOI | 10.1074/jbc.M111.227165 |
PII | S0021-9258(20)57528-5 |
PMID | 21697096 |
PMC | PMC3151056 |
MeSH | Active Transport, Cell Nucleus / physiology Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Nucleus / genetics Cell Nucleus / metabolism* Energy Metabolism / physiology Fatty Acid-Binding Proteins / genetics Fatty Acid-Binding Proteins / metabolism* Lipid Metabolism / physiology* Protein Binding Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism Stearic Acids / metabolism* Transcription, Genetic / physiology* |
IF | 4.238 |
引用数 | 9 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
線虫 | tm1618 |