論文 - 詳細
| RRC ID | 46544 |
|---|---|
| 著者 | Zaslaver A, Baugh LR, Sternberg PW. |
| タイトル | Metazoan operons accelerate recovery from growth-arrested states. |
| ジャーナル | Cell |
| Abstract |
Existing theories explain why operons are advantageous in prokaryotes, but their occurrence in metazoans is an enigma. Nematode operon genes, typically consisting of growth genes, are significantly upregulated during recovery from growth-arrested states. This expression pattern is anticorrelated to nonoperon genes, consistent with a competition for transcriptional resources. We find that transcriptional resources are initially limiting during recovery and that recovering animals are highly sensitive to any additional decrease in transcriptional resources. We provide evidence that operons become advantageous because, by clustering growth genes into operons, fewer promoters compete for the limited transcriptional machinery, effectively increasing the concentration of transcriptional resources and accelerating recovery. Mathematical modeling reveals how a moderate increase in transcriptional resources can substantially enhance transcription rate and recovery. This design principle occurs in different nematodes and the chordate C. intestinalis. As transition from arrest to rapid growth is shared by many metazoans, operons could have evolved to facilitate these processes. |
| 巻・号 | 145(6) |
| ページ | 981-92 |
| 公開日 | 2011-6-10 |
| DOI | 10.1016/j.cell.2011.05.013 |
| PII | S0092-8674(11)00539-3 |
| PMID | 21663799 |
| PMC | PMC3152313 |
| MeSH | Animals Ciona intestinalis / genetics Ciona intestinalis / growth & development Ciona intestinalis / metabolism Gene Expression Regulation* Models, Genetic Nematoda / genetics Nematoda / growth & development Nematoda / metabolism Operon* Transcription, Genetic |
| IF | 38.637 |
| 引用数 | 26 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3740 tm3893 |