| RRC ID |
46551
|
| Author |
Zhang X, Zabinsky R, Teng Y, Cui M, Han M.
|
| Title |
microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause.
|
| Journal |
Proc Natl Acad Sci U S A
|
| Abstract |
Environmental stresses and nutrition availability critically affect animal development. Numerous animal species across multiple phyla enter developmental arrest for long-term survival in unfavorable environments and resume development upon stress removal. Here we show that compromising overall microRNA (miRNA) functions or mutating certain individual miRNAs impairs the long-term survival of nematodes during starvation-induced L1 diapause. We provide evidence that miRNA miR-71 is not required for the animals' entry into L1 diapause, but plays a critical role in long-term survival by repressing the expression of insulin receptor/PI3K pathway genes and genes acting downstream or in parallel to the pathway. Furthermore, miR-71 plays a prominent role in developmental recovery from L1 diapause partly through repressing the expression of certain heterochronic genes. The presented results indicate that interactions between multiple miRNAs and likely a large number of their mRNA targets in multiple pathways regulate the response to starvation-induced L1 diapause.
|
| Volume |
108(44)
|
| Pages |
17997-8002
|
| Published |
2011-11-1
|
| DOI |
10.1073/pnas.1105982108
|
| PII |
1105982108
|
| PMID |
22011579
|
| PMC |
PMC3207661
|
| MeSH |
3' Untranslated Regions
Animals
Caenorhabditis elegans / cytology
Caenorhabditis elegans / genetics
Caenorhabditis elegans / physiology*
Cell Division
MicroRNAs / physiology*
Mutation
Starvation*
|
| IF |
9.412
|
| Times Cited |
54
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| C.elegans |
tm3681
tm2432 |
