RRC ID 46577
Author Chen L, Zhou S.
Title "CRASH"ing with the worm: insights into L1CAM functions and mechanisms.
Journal Dev Dyn
Abstract The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions and mechanisms of action. This review summarizes the discoveries of L1CAMs made in C. elegans, showcasing this simple model organism as a powerful system to uncover L1CAM mechanisms and roles in healthy and diseased states.
Volume 239(5)
Pages 1490-501
Published 2010-5-1
DOI 10.1002/dvdy.22269
PMID 20225255
PMC PMC3428060
MeSH Animals Caenorhabditis elegans Nervous System / growth & development Nervous System Diseases Neural Cell Adhesion Molecule L1 / physiology*
IF 3.275
Times Cited 17
WOS Category ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
Resource
C.elegans tm3056