Reference - Detail
| RRC ID | 46578 |
|---|---|
| Author | Choi MS, Yoo AS, Greenwald I. |
| Title | sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. |
| Journal | PLoS One |
| Abstract |
BACKGROUND:LIN-12/Notch signaling is important for cell-cell interactions during development, and mutations resulting in constitutive LIN-12/Notch signaling can cause cancer. Loss of negative regulators of lin-12/Notch activity has the potential for influencing cell fate decisions during development and the genesis or aggressiveness of cancer. METHODOLOGY/PRINCIPAL FINDINGS:We describe two negative modulators of lin-12 activity in C. elegans. One gene, sel-11, was initially defined as a suppressor of a lin-12 hypomorphic allele; the other gene, cdc-42, is a well-studied Rho GTPase. Here, we show that SEL-11 corresponds to yeast Hrd1p and mammalian Synoviolin. We also show that cdc-42 has the genetic properties consistent with negative regulation of lin-12 activity during vulval precursor cell fate specification. CONCLUSIONS/SIGNIFICANCE:Our results underscore the multiplicity of negative regulatory mechanisms that impact on lin-12/Notch activity and suggest novel mechanisms by which constitutive lin-12/Notch activity might be exacerbated in cancer. |
| Volume | 5(7) |
| Pages | e11885 |
| Published | 2010-7-29 |
| DOI | 10.1371/journal.pone.0011885 |
| PMID | 20686701 |
| PMC | PMC2912376 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Membrane Proteins / genetics Membrane Proteins / metabolism* Polymerase Chain Reaction RNA Interference Receptors, Notch |
| IF | 2.74 |
| Times Cited | 7 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| C.elegans | tm1743 |