RRC ID 46619
著者 Kasturi P, Zanetti S, Passannante M, Saudan Z, Müller F, Puoti A.
タイトル The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1.
ジャーナル Dev Biol
Abstract In the germ line of the Caenorhabditis elegans hermaphrodite, nuclei either proliferate through mitosis or initiate meiosis, finally differentiating as spermatids or oocytes. The production of oocytes requires repression of the fem-3 mRNA by cytoplasmic FBF and nuclear MOG proteins. Here we report the identification of the sex determining gene mog-3 and show that in addition to its role in gamete sex determination, it is necessary for meiosis by acting downstream of GLP-1/Notch. Furthermore, we found that MOG-3 binds both to the nuclear proteins MEP-1 and CIR-1. MEP-1 is necessary for oocyte production and somatic differentiation, while the mammalian CIR-1 homolog counters Notch signaling. We propose that MOG-3, MEP-1 and CIR-1 associate in a nuclear complex which regulates different aspects of germ cell development. While FBF triggers the sperm/oocyte switch by directly repressing the fem-3 mRNA in the cytoplasm, the MOG proteins play a more indirect role in the nucleus, perhaps by acting as epigenetic regulators or by controlling precise splicing events.
巻・号 344(2)
ページ 593-602
公開日 2010-8-15
DOI 10.1016/j.ydbio.2010.05.009
PII S0012-1606(10)00295-2
PMID 20478293
MeSH Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / growth & development Caenorhabditis elegans* / physiology Co-Repressor Proteins Germ Cells / metabolism Glucagon-Like Peptide 1 / genetics Glucagon-Like Peptide 1 / metabolism Male Meiosis Oocytes / metabolism Oocytes / physiology RNA Splicing RNA, Messenger / genetics RNA, Messenger / metabolism Spermatozoa / metabolism
IF 2.896
引用数 14
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
線虫 tm1601