論文 - 詳細
| RRC ID | 46695 |
|---|---|
| 著者 | Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N. |
| タイトル | Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development. |
| 巻・号 | 404(3) |
| ページ | 751-5 |
| 公開日 | 2011-1-21 |
| DOI | 10.1016/j.bbrc.2010.12.017 |
| PII | S0006-291X(10)02242-4 |
| PMID | 21144829 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism Cytochromes b Energy Metabolism* GTP Phosphohydrolases / metabolism Membrane Fusion* Mitochondria / physiology* Oxidative Stress* Protein Carbonylation Succinate Dehydrogenase / metabolism Superoxides / metabolism |
| IF | 2.985 |
| 引用数 | 8 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1133 |