RRC ID 46695
Author Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N.
Title Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans.
Journal Biochem Biophys Res Commun
Abstract Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development.
Volume 404(3)
Pages 751-5
Published 2011-1-21
DOI 10.1016/j.bbrc.2010.12.017
PII S0006-291X(10)02242-4
PMID 21144829
MeSH Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism Cytochromes b Energy Metabolism* GTP Phosphohydrolases / metabolism Membrane Fusion* Mitochondria / physiology* Oxidative Stress* Protein Carbonylation Succinate Dehydrogenase / metabolism Superoxides / metabolism
IF 2.985
Times Cited 8
C.elegans tm1133