| RRC ID |
46695
|
| 著者 |
Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N.
|
| タイトル |
Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development.
|
| 巻・号 |
404(3)
|
| ページ |
751-5
|
| 公開日 |
2011-1-21
|
| DOI |
10.1016/j.bbrc.2010.12.017
|
| PII |
S0006-291X(10)02242-4
|
| PMID |
21144829
|
| MeSH |
Animals
Caenorhabditis elegans / growth & development*
Caenorhabditis elegans Proteins / metabolism
Cytochromes b
Energy Metabolism*
GTP Phosphohydrolases / metabolism
Membrane Fusion*
Mitochondria / physiology*
Oxidative Stress*
Protein Carbonylation
Succinate Dehydrogenase / metabolism
Superoxides / metabolism
|
| IF |
2.985
|
| 引用数 |
8
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 線虫 |
tm1133 |
