Reference - Detail
| RRC ID | 46704 |
|---|---|
| Author | Zhou S, Chen L. |
| Title | Neural integrity is maintained by dystrophin in C. elegans. |
| Journal | J Cell Biol |
| Abstract |
The dystrophin protein complex (DPC), composed of dystrophin and associated proteins, is essential for maintaining muscle membrane integrity. The link between mutations in dystrophin and the devastating muscle failure of Duchenne's muscular dystrophy (DMD) has been well established. Less well appreciated are the accompanying cognitive impairment and neuropsychiatric disorders also presented in many DMD patients, which suggest a wider role for dystrophin in membrane-cytoskeleton function. This study provides genetic evidence of a novel role for DYS-1/dystrophin in maintaining neural organization in Caenorhabditis elegans. This neuronal function is distinct from the established role of DYS-1/dystrophin in maintaining muscle integrity and regulating locomotion. SAX-7, an L1 cell adhesion molecule (CAM) homologue, and STN-2/γ-syntrophin also function to maintain neural integrity in C. elegans. This study provides biochemical data that show that SAX-7 associates with DYS-1 in an STN-2/γ-syntrophin-dependent manner. These results reveal a recruitment of L1CAMs to the DPC to ensure neural integrity is maintained. |
| Volume | 192(2) |
| Pages | 349-63 |
| Published | 2011-1-24 |
| DOI | 10.1083/jcb.201006109 |
| PII | jcb.201006109 |
| PMID | 21242290 |
| PMC | PMC3172177 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cells, Cultured Cytoskeleton / metabolism Dystrophin / genetics Dystrophin / metabolism* Dystrophin-Associated Proteins / metabolism Humans Muscle, Skeletal / cytology Muscle, Skeletal / metabolism Neural Cell Adhesion Molecules / metabolism Neurons / cytology Neurons / metabolism* Protein Binding Two-Hybrid System Techniques |
| IF | 8.811 |
| Times Cited | 6 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Google+ |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1869 |