論文 - 詳細
| RRC ID | 46736 |
|---|---|
| 著者 | Park SK, Link CD, Johnson TE. |
| タイトル | Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. |
| ジャーナル | FASEB J |
| Abstract |
Recent studies have shown that the rate of aging can be modulated by diverse interventions. Dietary restriction is the most widely used intervention to promote longevity; however, the mechanisms underlying the effect of dietary restriction remain elusive. In a previous study, we identified two novel genes, nlp-7 and cup-4, required for normal longevity in Caenorhabditis elegans. nlp-7 is one of a set of neuropeptide-like protein genes; cup-4 encodes an ion-channel involved in endocytosis by coelomocytes. Here, we assess whether nlp-7 and cup-4 mediate longevity increases by dietary restriction. RNAi of nlp-7 or cup-4 significantly reduces the life span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span of long-lived mutants resulting from reduced insulin/IGF-1 signaling or dysfunction of the mitochondrial electron transport chain. The life-span extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevented significantly in nlp-7 and cup-4 mutants. RNAi knockdown of genes encoding candidate receptors of NLP-7 and genes involved in endocytosis by coelomocytes also specifically shorten the life span of the eat-2 mutant. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans. |
| 巻・号 | 24(2) |
| ページ | 383-92 |
| 公開日 | 2010-2-1 |
| DOI | 10.1096/fj.09-142984 |
| PII | fj.09-142984 |
| PMID | 19783783 |
| PMC | PMC2812037 |
| MeSH | Aging / drug effects Aging / physiology Animals Caenorhabditis elegans / cytology Caenorhabditis elegans Proteins / physiology* Caloric Restriction Endocytosis / physiology* Longevity / genetics* Neuropeptides / physiology* Oxidative Stress RNA Interference Signal Transduction / physiology* |
| IF | 4.966 |
| 引用数 | 33 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2984 tm2990 |