| RRC ID |
46740
|
| 著者 |
Solinger JA, Paolinelli R, Klöss H, Scorza FB, Marchesi S, Sauder U, Mitsushima D, Capuani F, Stürzenbaum SR, Cassata G.
|
| タイトル |
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
Although acetylated alpha-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate alpha-tubulin acetylation are, to date, largely unknown. Therefore, a genetic screen was employed in the nematode Caenorhabditis elegans that identified the Elongator complex as a possible regulator of alpha-tubulin acetylation. Detailed characterization of mutant animals revealed that the acetyltransferase activity of the Elongator is indeed required for correct acetylation of microtubules and for neuronal development. Moreover, the velocity of vesicles on microtubules was affected by mutations in Elongator. Elongator mutants also displayed defects in neurotransmitter levels. Furthermore, acetylation of alpha-tubulin was shown to act as a novel signal for the fine-tuning of microtubules dynamics by modulating alpha-tubulin turnover, which in turn affected neuronal shape. Given that mutations in the acetyltransferase subunit of the Elongator (Elp3) and in a scaffold subunit (Elp1) have previously been linked to human neurodegenerative diseases, namely Amyotrophic Lateral Sclerosis and Familial Dysautonomia respectively highlights the importance of this work and offers new insights to understand their etiology.
|
| 巻・号 |
6(1)
|
| ページ |
e1000820
|
| 公開日 |
2010-1-22
|
| DOI |
10.1371/journal.pgen.1000820
|
| PMID |
20107598
|
| PMC |
PMC2809763
|
| MeSH |
Acetylation
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Histone Acetyltransferases / genetics
Histone Acetyltransferases / metabolism*
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Neurons / metabolism*
Protein Binding
RNA-Binding Proteins
Tubulin / genetics
Tubulin / metabolism*
|
| IF |
5.175
|
| 引用数 |
70
|
|
WOS 分野
|
GENETICS & HEREDITY
|
| リソース情報 |
| 線虫 |
tm3120 |
