RRC ID 46760
著者 Li M, Lindblad JL, Perez E, Bergmann A, Fan Y.
タイトル Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.
ジャーナル BMC Biol
Abstract BACKGROUND:ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.
RESULTS:Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.
CONCLUSION:In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.
巻・号 14
ページ 70
公開日 2016-8-19
DOI 10.1186/s12915-016-0293-y
PII 10.1186/s12915-016-0293-y
PMID 27542914
PMC PMC4992243
MeSH Animals Apoptosis* Autophagy* Autophagy-Related Protein-1 Homolog / genetics Autophagy-Related Protein-1 Homolog / metabolism* Cell Proliferation Drosophila / genetics* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Eye / growth & development Imaginal Discs / growth & development MAP Kinase Signaling System Transcriptional Activation Wings, Animal / growth & development
IF 6.765
引用数 11
WOS 分野 BIOLOGY
リソース情報
ショウジョウバエ 9746R-2