論文 - 詳細
RRC ID | 46760 |
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著者 | Li M, Lindblad JL, Perez E, Bergmann A, Fan Y. |
タイトル | Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation. |
ジャーナル | BMC Biol |
Abstract |
BACKGROUND:ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer. RESULTS:Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development. CONCLUSION:In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP. |
巻・号 | 14 |
ページ | 70 |
公開日 | 2016-8-19 |
DOI | 10.1186/s12915-016-0293-y |
PII | 10.1186/s12915-016-0293-y |
PMID | 27542914 |
PMC | PMC4992243 |
MeSH | Animals Apoptosis* Autophagy* Autophagy-Related Protein-1 Homolog / genetics Autophagy-Related Protein-1 Homolog / metabolism* Cell Proliferation Drosophila / genetics* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Eye / growth & development Imaginal Discs / growth & development MAP Kinase Signaling System Transcriptional Activation Wings, Animal / growth & development |
IF | 6.765 |
引用数 | 11 |
WOS 分野 | BIOLOGY |
リソース情報 | |
ショウジョウバエ | 9746R-2 |