Reference - Detail
| RRC ID | 46761 |
|---|---|
| Author | Shih HT, Chen WY, Liu KY, Shih ZS, Chen YJ, Hsieh PC, Kuo KL, Huang KH, Hsu PH, Liu YW, Chan SP, Lee HH, Tsai YC, Wu JT. |
| Title | dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations. |
| Journal | PLoS Genet |
| Abstract |
To maintain a particular cell fate, a unique set of genes should be expressed while another set is repressed. One way to repress gene expression is through Polycomb group (PcG) proteins that compact chromatin into a silent configuration. In addition to cell fate maintenance, PcG proteins also maintain normal cell physiology, for example cell cycle. In the absence of PcG, ectopic activation of the PcG-repressed genes leads to developmental defects and malignant tumors. Little is known about the molecular nature of ectopic gene expression; especially what differentiates expression of a given gene in the orthotopic tissue (orthotopic expression) and the ectopic expression of the same gene due to PcG mutations. Here we present that ectopic gene expression in PcG mutant cells specifically requires dBRWD3, a negative regulator of HIRA/Yemanuclein (YEM)-mediated histone variant H3.3 deposition. dBRWD3 mutations suppress both the ectopic gene expression and aberrant tissue overgrowth in PcG mutants through a YEM-dependent mechanism. Our findings identified dBRWD3 as a critical regulator that is uniquely required for ectopic gene expression and aberrant tissue overgrowth caused by PcG mutations. |
| Volume | 12(9) |
| Pages | e1006262 |
| Published | 2016-9-1 |
| DOI | 10.1371/journal.pgen.1006262 |
| PII | PGENETICS-D-15-02868 |
| PMID | 27588417 |
| PMC | PMC5010193 |
| MeSH | Animals Cell Cycle / genetics* Cell Cycle Proteins / biosynthesis Cell Cycle Proteins / genetics Cell Differentiation / genetics* Chromatin / genetics DNA-Binding Proteins / biosynthesis DNA-Binding Proteins / genetics Drosophila Proteins / biosynthesis Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Eye / growth & development Eye / metabolism Gene Expression Regulation, Developmental Histone Chaperones / biosynthesis Histone Chaperones / genetics Histones / genetics Imaginal Discs / growth & development Imaginal Discs / metabolism Mutation Nuclear Proteins / biosynthesis Nuclear Proteins / genetics Polycomb-Group Proteins / biosynthesis Polycomb-Group Proteins / genetics* Transcription Factors / biosynthesis Transcription Factors / genetics* |
| IF | 5.175 |
| Times Cited | 1 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 3886R-4 18412R-1 6502R-3 32443R-1 7405R-1 3319R-1 |