RRC ID 46790
Author Kubota T, Watase S, Sakai K, Fromont J, Gonoi T, Kobayashi J.
Title Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge.
Journal Bioorg Med Chem Lett
Abstract Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity.
Volume 25(22)
Pages 5221-3
Published 2015-11-15
DOI 10.1016/j.bmcl.2015.09.061
PII S0960-894X(15)30095-0
PMID 26459215
MeSH Alkaloids / chemistry* Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Antifungal Agents / chemistry* Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Aspergillus niger / drug effects Cryptococcus neoformans / drug effects Porifera Tyrosine / analogs & derivatives* Tyrosine / chemistry Tyrosine / isolation & purification Tyrosine / pharmacology
IF 2.448
Times Cited 5
Pathogenic microorganisms NA