論文 - 詳細
RRC ID | 46809 |
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著者 | Kusama T, Tanaka N, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. |
タイトル | Bromopyrrole alkaloids from a marine sponge Agelas sp. |
ジャーナル | Chem Pharm Bull (Tokyo) |
Abstract |
Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1-5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1-3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated. |
巻・号 | 62(5) |
ページ | 499-503 |
公開日 | 2014-1-1 |
DOI | 10.1248/cpb.c14-00077 |
PII | DN/JST.JSTAGE/cpb/c14-00077 |
PMID | 24789935 |
MeSH | Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology* Animals Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Antifungal Agents / chemistry Antifungal Agents / isolation & purification Antifungal Agents / pharmacology* Bacteria / drug effects Dose-Response Relationship, Drug Fungi / drug effects Hydrocarbons, Brominated / chemistry Hydrocarbons, Brominated / isolation & purification Hydrocarbons, Brominated / pharmacology* Microbial Sensitivity Tests Molecular Structure Porifera / chemistry* Pyrroles / chemistry Pyrroles / isolation & purification Pyrroles / pharmacology* Structure-Activity Relationship |
IF | 1.416 |
引用数 | 17 |
WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY CHEMISTRY, MULTIDISCIPLINARY |
リソース情報 | |
病原微生物 |