RRC ID 46822
Author Suzuki H, Kubota T, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J.
Title Nakijiquinone S and nakijinol C, new meroterpenoids from a marine sponge of the family spongiidae.
Journal Chem Pharm Bull (Tokyo)
Abstract New meroterpenoids, nakijiquinone S (1) and nakijinol C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures and relative stereochemistries of 1 and 2 were elucidated on the basis of their spectral data. Nakijiquinone S (1) and nakijinol C (2) were new meroterpenoids consisting of a clerodane-type decalin ring connected to a 2-butoxy-5-hydroxy-benzoquinone unit or methyl 2,3,4-trihydroxybenzoate unit through a methylene, respectively. Nakijiquinone S (1) and nakijinol C (2) showed antimicrobial activities against several bacteria and fungi.
Volume 62(2)
Pages 209-12
Published 2014-1-1
DOI 10.1248/cpb.c13-00810
PII DN/JST.JSTAGE/cpb/c13-00810
PMID 24492592
MeSH Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology* Bacteria / drug effects Bacterial Infections / drug therapy Benzoquinones / chemistry* Benzoquinones / isolation & purification Benzoquinones / pharmacology* Fungi / drug effects Models, Molecular Mycoses / drug therapy Porifera / chemistry* Pyrogallol / analogs & derivatives* Pyrogallol / chemistry Pyrogallol / isolation & purification Pyrogallol / pharmacology Sesquiterpenes / chemistry* Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology*
IF 1.416
Times Cited 2
Pathogenic microorganisms