RRC ID 46855
Author Kubota T, Ishiguro Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J.
Title Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
Journal Bioorg Med Chem Lett
Abstract Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.
Volume 23(1)
Pages 244-7
Published 2013-1-1
DOI 10.1016/j.bmcl.2012.10.109
PII S0960-894X(12)01411-4
PMID 23186727
MeSH Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology Bacteria / drug effects Bone Marrow Cells / cytology Dendritic Cells / cytology Dendritic Cells / drug effects Dendritic Cells / metabolism Fatty Acids / chemistry* Fatty Acids / isolation & purification Fatty Acids / pharmacology Fungi / drug effects Indenes / chemistry* Indenes / isolation & purification Indenes / pharmacology Interleukin-12 / metabolism Interleukin-6 / metabolism Japan Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Molecular Conformation Plakortis / chemistry* Polyketides / chemistry* Polyketides / isolation & purification Polyketides / pharmacology Tumor Necrosis Factor-alpha / metabolism
IF 2.572
Times Cited 7
Pathogenic microorganisms NA