| RRC ID |
46855
|
| 著者 |
Kubota T, Ishiguro Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J.
|
| タイトル |
Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
|
| ジャーナル |
Bioorg Med Chem Lett
|
| Abstract |
Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.
|
| 巻・号 |
23(1)
|
| ページ |
244-7
|
| 公開日 |
2013-1-1
|
| DOI |
10.1016/j.bmcl.2012.10.109
|
| PII |
S0960-894X(12)01411-4
|
| PMID |
23186727
|
| MeSH |
Animals
Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Bacteria / drug effects
Bone Marrow Cells / cytology
Dendritic Cells / cytology
Dendritic Cells / drug effects
Dendritic Cells / metabolism
Fatty Acids / chemistry*
Fatty Acids / isolation & purification
Fatty Acids / pharmacology
Fungi / drug effects
Indenes / chemistry*
Indenes / isolation & purification
Indenes / pharmacology
Interleukin-12 / metabolism
Interleukin-6 / metabolism
Japan
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred C57BL
Molecular Conformation
Plakortis / chemistry*
Polyketides / chemistry*
Polyketides / isolation & purification
Polyketides / pharmacology
Tumor Necrosis Factor-alpha / metabolism
|
| IF |
2.572
|
| 引用数 |
7
|
|
WOS 分野
|
CHEMISTRY, MEDICINAL
CHEMISTRY, ORGANIC
|
| リソース情報 |
| 病原微生物 |
NA |
