論文 - 詳細
| RRC ID | 46867 |
|---|---|
| 著者 | Tanaka N, Kusama T, Takahashi-Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. |
| タイトル | Nagelamides X-Z, dimeric bromopyrrole alkaloids from a marine sponge Agelas sp. |
| ジャーナル | Org Lett |
| Abstract |
Three new dimeric bromopyrrole alkaloids, nagelamides X-Z (1-3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides X-Z (1-3) exhibited antimicrobial activity. |
| 巻・号 | 15(13) |
| ページ | 3262-5 |
| 公開日 | 2013-7-5 |
| DOI | 10.1021/ol401291n |
| PMID | 23767821 |
| MeSH | Agelas / chemistry* Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology* Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification* Anti-Infective Agents / pharmacology Dimerization Magnetic Resonance Spectroscopy Molecular Structure Pyrroles / chemistry Pyrroles / isolation & purification* Pyrroles / pharmacology* Spiro Compounds / chemistry Spiro Compounds / isolation & purification* Spiro Compounds / pharmacology* |
| IF | 6.091 |
| 引用数 | 28 |
| WOS 分野 | CHEMISTRY, ORGANIC |
| リソース情報 | |
| 病原微生物 | NA |